KINYO PHARMACEUTICAL CO., LTD.KINYO PHARMACEUTICAL CO., LTD.

CONTACT US

PROCESS

Manufacturing Process of Drinks

The Techno Nara Factory was completed in December 1999 as a cutting-edge fully automated factory based on rigorous GMP standards.

  • (20mL,30mL,45mL,50mL) bottles Production flow chart
  • (70mL,100mL) bottles Production flow chart
  • Measuring weight
    Measuring weight
    Preparation
    Preparation500Lor1500L Jacketed preparation tank:
    Dissolving condition:
    Ex)raw materials→80℃・20~30min  Heating and mixing. Around 70℃ Add Vitamins,flavors and mixing 10 min. Fill up to 500L or 1500L(around 40℃)
    Sterilization
    SterilizationShell & tube type Heat exchanger
    Sterilization condition:
    Ex)85℃・30sec
    Bottle rinsing
    Bottle rinsingFinal rinse water
    Temperature: 80℃

    Filtration: 150Mesh

    Filling / capping
    Filling / cappingSpeed: 150or180B.P.M
    Volume: 20mL, 30mL, 45mL, 50mL
    Cap closing: cap screw depth・opening torque/Nitrogen Substitution rate
    Visual inspection
    Visual inspectionDefective caps(shallowed screw depth.scratch), Volume, foreign material, Scratched bottles, Visual inspection by human
    Post sterilization(pasteurizer)
    Post sterilization(pasteurizer)Heated Water shower type method
    Temperature: ex)85℃
    Passage time: around 30min
    Labeling(keeping intermediate products)
    Labeling(keeping intermediate products)Coated adhesive label or glue label/Manufacturing Number Exp. date(heat transfer printing: inked ribbon)
    Check the seal by a camera

    Move the products to packing room

    Packing
    Move the products to packing roomPacking by the machine automatically(1-3bottles/1box and 10bottles/1box)
    Sealing Manufacturing number and exp.date/ checking the weight
    Sealing Manufacturing number and exp.date/ checking the weightSealing the Manufacturing Number and Exp. date
    Sealing by ink-jet printer or Laser Marker/checking the weight
    Final packing
    Final packingEx)Packing 1box×6 (with bottom pad)by manual
    Sealing Manufacturing Number and Exp. date
    Storage/Shipment judgement
    Storage/Shipment judgementCertification of analysis(ex.Brix, pH, appearance, standard plate count[coliform group], Eumycetes: cultivating 7days)
    Shipping

    Pipe line

    Production line

  • Measuring weight
    Measuring weight
    Preparation
    Preparation5000L Jacketed preparation tank:Dissolving
    condition:
    Ex)Heating and mixing. Around 70℃ Add Vitamins, flavors and mixing 30 min. Fill up (around 70℃)
    Sterilization
    SterilizationPlate type heat exchanger
    Sterilization condition:
    Ex)92℃・3sec
    Bottle rinsing
    Bottle rinsingFinal rinse water
    Temperature: 80℃

    Filtration: 100Mesh

    Filling / capping
    Filling / cappingspeed: 250B.P.M
    Volume: 70mL,100mL
    Cap closing: cap screw depth・opening torque
    Visual inspection
    Visual inspectionDefective caps(shallowed screw depth・scratch), Volume, foreign material, Scratched bottles, Visual inspection by human
    Labeling(keeping intermediate products)
    Labeling(keeping intermediate products)glue label/manufacturing Number・Exp. date
    Check the seal by a camera

    Move the products to packing room

    Wrapping / Packing
    Sealing Manufacturing number and exp.date / checking the weight
    Wrapping / Packing / Sealing Manufacturing number and exp.date / checking the weightWrapping/Packing by the machine automatically
    10bottles/box
    5boxes/cardboard box
    Sealing the Manufacturing Number and Exp. date by Laser Marker
    Checking the weight
    Storage / Shipment judgement
    Storage / Shipment judgementLoad the product to the pallet by Palletizer and store in the automatic ware house
    Certification of analysis
    Shipping

    Pipe line

    Production line

Page top